简介：In summary, the Japanese strategies for preventing HCC development is; i) eradicate the possible as early as possible since the adherence to the standard antiviral treatment is poor in elderly patients with HCV, ii) perform social education for understanding the natural course of HCV infection to accept the early eradicative treatment, iii) establish the social supportive program to receive antiviral therapy (both medical and economical), and iv) develop interferon free based antiviral treatment to increase the adherence of antiviral therapy in elderly populations.