简介：Hepatology Digest: We are able to achieve viral suppression with the use of NAs and IFN in chronic hepatitis B infected patients. However， while many benefit from antiviral therapy in clinical practice， there are long-term problems with therapy that include side effects， low response rates， and an inability to eradicate the cccDNA in hepatocytes. With regard to new novel targets for therapy， what parts of the HBV replication process should research be focusing on?